New Synthesis of Diazepam and the Related 1,4-Benzodiazepines by means of Palladium-Catalyzed Carbonylation

DOI: 10.1021/jo00133a042

Source and publish data:

Journal of Organic Chemistry p. 2456 - 2461 (1982)

Update date:2022-08-02

Topics: Synthesis Palladium-Catalyzed Carbonylation Experimental 1,4-Benzodiazepines

Authors:

Ishikura, Minoru

Mori, Miwako

Ikeda, Toshihito

Terashima, Masanao

Ban, Yoshio

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00133a042

A new synthesis of diazepam (5) was achieved by application of palladium-catalyzed carbonylation to the compound 3 prepared from o-bromoaniline derivative 1 and the amino acid 2, and this procedure was also used for the synthesis of poisonous metabolites

Full text of DOI:10.1021/jo00133a042

Products guided by the article

Product name:4-benzyl-7-chloro-3,4-dihydro-1-methyl-1,4-benzodiazepine-2,5-dione

Cas No:79844-45-4

R&D Labs maybe for 79844-45-4

Li's chemicals

Contact:+86-15850770348

Address:51 OF XIANGFANGCUN ROAD, Nanjing 210002, China
Tianjin Dongchang Fine Chemical Industry Co., Ltd.

Contact:+86-22-29894595

Address:Economic Developing Zone, Ji County, Tianjin, China
Hangzhou Dingyan Chem Co., Ltd

website:http://www.dingyanchem.com

Contact:86-571-87157530

Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004
TIANJIN FESTO CHEMICAL CO.,LTD(expird)

Contact:86-22-25814570

Address:No.12th,5th Ave.,TEDA,Tianjin,China
Antaeus Bio-technology Co., LTD(expird)

Contact:021-31252569

Address:shanghai pudong

Relevant to this article

1,2-CARBONYL TRANSPOSITION OF cis-BICYCLO<3.3.0>OCTAN-2-ONE TO ITS 3-ONE SKELETON: APPLICATION TO SYNTHESES OF dl-HIRSUTIC ACID AND dl-9(O)-METHANOPROSTACYCLIN

Doi:10.1246/cl.1981.1245
(1981)
Regio- and Stereocontrolled Synthesis of 3-Substituted 1,2-Diazetidines by Asymmetric Allylic Amination of Vinyl Epoxide

Doi:10.1021/acs.orglett.7b00653
(2017)
Ion Pair Effects in an Intercalation Process. An Approach to the Bicyclo<5.3.1>undecyl System of Taxane

Doi:10.1021/ja00367a056
(1982)
Sequential coupling of zincated hydrazone, alkenylboronate, and electrophile that creates several contiguous stereogenic centers

Doi:10.1021/ja044878s
(2004)
Reactions of 5,6-Dilithioacenaphthene-N,N,N',N'-Tetramethyl-1,2-ethanediamine Complex with α-Diketones. I. cis-Directing 1:1 Cyclic Additions with Acyclic and Cyclic α-Diketones and Related Compounds

Doi:10.1246/bcsj.54.3020
(1981)
Synthesis, structure and reactivity of tris-, bis- and mono(2,4- dimethylpentadienyl) complexes of neodymium, lanthanum and yttrium

Doi:10.1002/zaac.200700056
(2007)

Article Doi