New Synthesis of Diazepam and the Related 1,4-Benzodiazepines by means of Palladium-Catalyzed Carbonylation

DOI: 10.1021/jo00133a042

Source and publish data:

Journal of Organic Chemistry p. 2456 - 2461 (1982)

Update date:2022-08-02

Topics: Synthesis Palladium-Catalyzed Carbonylation Experimental 1,4-Benzodiazepines

Authors:

Ishikura, Minoru

Mori, Miwako

Ikeda, Toshihito

Terashima, Masanao

Ban, Yoshio

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Article abstract of DOI:10.1021/jo00133a042

A new synthesis of diazepam (5) was achieved by application of palladium-catalyzed carbonylation to the compound 3 prepared from o-bromoaniline derivative 1 and the amino acid 2, and this procedure was also used for the synthesis of poisonous metabolites

Full text of DOI:10.1021/jo00133a042

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