Lipophilic Diamides as Ionophores for Alkali and Alkaline Earth Metal Cations

Article abstract of DOI:10.1002/hlca.19820650211

A sries of lipophilic N,N,N',N'-tetrasubstituted diamides were prepared and their selectivity in solvent polymeric membranes was studied. cis-N,N,N',N'-Tetraisobutylcyclohexane-1,2-dicarboxamide includes a selectivity in membranes for Li⁺ over alkaline earth metal cations and other alkali metal cations by a factor of about 1000 and 100 respectively.The ionophore N,N'-diheptyl-N,N'-dimethylethylmalonamide is an attractive candidate for the use in microelectrodes for the determination of intracellular Mg²⁺-activities.