ENANTIOSELECTIVE SYNTHESIS OF β-HYDROXYISOBUTYRIC ACID: A USEFUL SYNTHON IN THE SYNTHESIS OF POLYPROPIONATE-TYPE NATURAL PRODUCTS

DOI: 10.1016/S0040-4039(01)81956-0

Source and publish data:

Tetrahedron Letters p. 3555 - 3556 (1981)

Update date:2022-08-03

Topics:

Authors:

Choy, William

Ma, Philip

Masamune, Satoru

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Article abstract of DOI:10.1016/S0040-4039(01)81956-0

The aldol reaction of formaldehyde with the dicyclopentylborinyl enolate derived from S-(or R-) 1-tert-butyldimethylsilyloxy-1-cyclohexylbutan-2-one, followed by desilylation and sodium meta-periodate oxidation, provides R-(or S-) β-hydroxyisobutyric acid.

Full text of DOI:10.1016/S0040-4039(01)81956-0

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