Aldol additions of pinacolone lithium enolate with ketones: Reactivities governed predominantly by field effects

Article abstract of DOI:10.1021/ja00057a012

The relative reactivities of representative α- and β-heterosubstituted acyclic, cyclic (five- and six-membered), and aromatic ketones with the lithium enolate of pinacolone in diethyl ether at -78 °C were determined. The order of reactivities of monosubst