Journal of Organic Chemistry p. 1812 - 1816 (1982)
Update date:2022-08-03
Topics:
Boggs, Norman T.
Bruton, H. David
Craig, Daniel H.
Helpern, Joseph A.
Marsh, Henry C.
et al.
At acidic pH the γ-proton of the γ-carboxyglutamic acid (Gla) side chain undergoes rapid exchange.We have utilized the reactivity of the resulting enol form to develop a method for the chemical modification of peptide-bound Gla residues.Reaction of Gla pe
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