New carboxyalkyl inhibitors of brain enkephalinase: Synthesis, biological activity, and analgesic properties

DOI: 10.1021/jm00355a013

Source and publish data:

Journal of Medicinal Chemistry p. 60 - 65 (1983)

Update date:2022-08-03

Topics:

Authors:

Fournie Zaluski

Chaillet

Soroca Lucas

Fournie-Zaluski

Marcais-Collado

Costentin

Roques Roques

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Article abstract of DOI:10.1021/jm00355a013

New carboxylalkyl compounds derived from Phe-Leu and Phe-Ala were synthesized and checked as inhibitors of enkephalinase, a metalloendopeptidase cleaving the Gly³-Phe⁴ bond of enkephalins from mouse striatal membranes. Differential r

Full text of DOI:10.1021/jm00355a013

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