Direction of 3-bromothiophene acylation with succinyl chloride

Article abstract of DOI:10.1007/s10593-013-1258-5

In the reaction of 3-bromothiophene with succinyl chloride in the presence of AlCl₃, a mixture of three isomeric dibromo-substituted 1,4-di(2-thienyl)butane-1,4-diones was formed. The main component was the unsymmetrical 1-(3-bromo-2-thienyl)-4-(4-bromo-2-thienyl)butane-1,4-dione rather than 1,4-di-(3-bromo-2-thienyl)butane-1,4-dione expected according to the orientation rules.