Design of potent and selective antagonists of the vasopressor responses to arginine-vasopressin

DOI: 10.1021/jm00346a015

Source and publish data:

Journal of Medicinal Chemistry p. 408 - 414 (1982)

Update date:2022-08-05

Topics: In vitro Testing Compound Library High-Throughput Screening In Vivo Testing Medicinal Chemistry Optimization Pharmacokinetics and Toxicity Clinical Development Formulation and Delivery Post-Marketing Surveillance

Authors:

Manning Manning

Lammek Lammek

Kruszynski

Seto Seto

Sawyer Sawyer

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Article abstract of DOI:10.1021/jm00346a015

The authors have synthesized eight new 1-β,β-dialkyl-substituted analogues of [1-deamino]arginine-vasopressin (dAVP) to determine some of the structural features that account for antivasopressor potency and that improve selectivity by reducing antidiureti

Full text of DOI:10.1021/jm00346a015

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