Preparation of (-)-(7R)-7-Acetyl-7-hydroxy-4,4-dimethoxy-5,6,7,8-tetrahydronaphthalen-1(4H)-one, a Chiral AB-Synthon for Anthracycline Synthesis

DOI: 10.1039/c39810001100

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1100 - 1101 (1981)

Update date:2022-08-05

Topics:

Authors:

Warrener, Ronald N.

Gee, Paul S.

Russell, Richard A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39810001100

The (-)-(R)-dienone (13) was prepared in 10 steps from the known 8-hydroxy-5-methoxy-2,3-dihydronaphthalen-1(4H)-one (2), and the chirality at C(7) in (13) corresponds to that found at C(9) in the naturally occurring anthracyclines related to daunomycin.

Full text of DOI:10.1039/c39810001100

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:8-benzyloxy-5-methoxy-3,4-dihydronaphthalen-1(2H)-one

Cas No:81504-89-4

R&D Labs maybe for 81504-89-4

WUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.

Contact:13861062998

Address:Room 1316,No.1619 Huishan Avenue,Wuxi,China
Shandong Yaroma Perfumery Co., Ltd.

Contact:+86- 531- 88024598

Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China
Jiangxi Huashi Pharmaceutical Co., Ltd

Contact:+86-795-4509628

Address:Ningbo Ave., Fengtian Industrial Park, Fengxin Country, Jiangxi, China.
Shanghai FWD Chemicals ltd

website:http://www.fwdchem.com

Contact:86-21-54450828

Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
Sichuan Mianzhu Ronghong Chemical Co.,LTd

Contact:8613981840544

Address:XINSHI INDUSTRY PARK,MIANZHU,SICHUAN,CHINA

Relevant to this article

Preparation and characterization of π-stacking quinodimethane oligothiophenes. Predicting semiconductor behavior and bandwidths from crystal structures and molecular orbital calculations

Doi:10.1021/ja0484597
(2004)
Captodative Substitution and Cyclopropane Geometry. Part 5. X-Ray Structure of Five New Compounds and Asymmetry Parameters of the Substituents

Doi:10.1039/P29880001045
(1988)
Stereoselective reactions. IX. Synthetic studies on optically active β-lactams. I. Chiral synthesis of carbapenam and carbapenem ring systems starting from (S)-aspartic acid

Doi:10.1248/cpb.33.3299
(1985)
Rearrangement of 3,3-Disubstituted 1-Aryl-4,5-dihydro-5-oxo-3H-1,2,4-triazolium Tetrafluoroborates; Part 2. A Convenient Synthesis of 1,5-Annulated 1,2-Dihydro-2-phenyl-3H-1,2,4-triazol-3-ones

Doi:10.1055/s-1990-27022
(1990)
An oligo vicinal diimine by the ehrlich-sachs reaction of a β-iminoketone with nitrosobenzene

Doi:10.1080/00304949609356547
(1996)
Design, synthesis and binding properties of novel and selective 5-HT₃ and 5-HT₄ receptor ligands

Doi:10.1016/S0223-5234(00)01187-9
(2000)

Article Doi