Preparation of (-)-(7R)-7-Acetyl-7-hydroxy-4,4-dimethoxy-5,6,7,8-tetrahydronaphthalen-1(4H)-one, a Chiral AB-Synthon for Anthracycline Synthesis

DOI: 10.1039/c39810001100

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1100 - 1101 (1981)

Update date:2022-08-05

Topics:

Authors:

Warrener, Ronald N.

Gee, Paul S.

Russell, Richard A.

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Article abstract of DOI:10.1039/c39810001100

The (-)-(R)-dienone (13) was prepared in 10 steps from the known 8-hydroxy-5-methoxy-2,3-dihydronaphthalen-1(4H)-one (2), and the chirality at C(7) in (13) corresponds to that found at C(9) in the naturally occurring anthracyclines related to daunomycin.

Full text of DOI:10.1039/c39810001100

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