Farnesyl Derivatives of Rigid Carboxylic Acids-Inhibitors of ras-Dependent Cell Growth

Article abstract of DOI:10.1021/jm00008a004

Inhibitors of the enzyme that methylates ras proteins, the prenylated protein methyltransferase (PPMTase), are described.They are fernesyl derivatives of rigid carboxylic acids that recognize the farnesylcysteine recognition domain of the enzyme but do no