Farnesyl Derivatives of Rigid Carboxylic Acids-Inhibitors of ras-Dependent Cell Growth

DOI: 10.1021/jm00008a004

Source and publish data:

Journal of Medicinal Chemistry p. 1267 - 1272 (1995)

Update date:2022-08-04

Topics:

Authors:

Marciano, Daniella

Ben-Baruch, Gilad

Marom, Michal

Egozi, Yaakov

Haklai, Roni

Kloog, Yoel

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Article abstract of DOI:10.1021/jm00008a004

Inhibitors of the enzyme that methylates ras proteins, the prenylated protein methyltransferase (PPMTase), are described.They are fernesyl derivatives of rigid carboxylic acids that recognize the farnesylcysteine recognition domain of the enzyme but do no

Full text of DOI:10.1021/jm00008a004

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