Molecular design of biologically active compounds based on platelet activating factor (PAF): 7-Oxabicyclo[2.2.1]heptane system as a strong antagonist of PAF

DOI: 10.1248/cpb.40.2891

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2891 - 2893 (1992)

Update date:2022-08-04

Topics:

Authors:

Kobayashi

Eguchi Eguchi

Sato Sato

Kudo Kudo

Inoue Inoue

Ohno Ohno

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.2891

7-Oxabicyclo[2.2.1]heptane system was designed based on the PAF structure. Among four stereoisomers synthesized, the diexo derivative turned out to be a new and strong antagonist of PAF.

Full text of DOI:10.1248/cpb.40.2891

NII-Electronic Library Service

Products guided by the article

Product name:exo-2,3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene

Cas No:817201-06-2

R&D Labs maybe for 817201-06-2

Shanghai Profirst Co., Ltd.

Contact:+86-21-38122007

Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
Sinochem Jiangsu Co.,Ltd.

Contact:86-25-51817806

Address:No. 216, middle longpan road, jincheng tower, floor 21-22, nanjing ,china
Hunan Shineway Enterprise Co., Ltd.

Contact:+86-731-86303875

Address:118, Huanghua International Airport Road, Huanghua Town, Changsha, Hunan 410137, China
Synasia Inc

Contact:17316303296

Address:240 Amboy Ave
Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning

Relevant to this article

An Efficient Synthesis of Ellipticine

Doi:10.1021/jo00135a034
(1982)
Selective C?N Bond Cleavage of N-Acylisatins: Towards High Performance Acylation/Arylation/Transamination Reagents

Doi:10.1002/adsc.201900819
(2019)
Geometric and electronic structures of phenoxyl radicals hydrogen bonded to neutral and cationic partners

Doi:10.1002/chem.201102854
(2012)
Synthesis of Racemic (E)- and (Z)-1-Amino-2-phenylcyclopropanecarboxylic Acid: (E)- and (Z)-"Cyclopropylphenylalanine"

Doi:10.1021/jo00138a014
(1982)
The Oxime Rearrangement Cyclization. Synthesis of Alkylidene-Δ¹-pyrrolines

Doi:10.1021/jo00185a022
(1984)
Water-binding solid scintillators: Synthesis, emission properties, and tests in ³H and ¹⁴C counting

Doi:10.1002/1521-3765(20000804)6:15<2809::AID-CHEM2809>3.0.CO;2-M
(2000)

Article Doi