Synthesis, X-Ray Crystallographic Determination, and Opioid Activity of erythro-5-Methylmethadone Enantiomers. Evidence Which Suggests That μ and δ Opioid Receptors Possess Different Stereochemical Requirements

DOI: 10.1021/jm00348a015

Source and publish data:

Journal of Medicinal Chemistry p. 684 - 688 (1982)

Update date:2022-08-03

Topics:

Authors:

Portoghese, P. S.

Poupaert, J. H.

Larson, D. L.

Groutas, W. C.

Meitzner, G. D.

et al. et al.

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Article abstract of DOI:10.1021/jm00348a015

Enantiomers of erythro-5-methylmethadone (3) were synthesized from optical antipodes of erythro-3-(dimethylamino)-2-butanol.X-ray crystallographic analysis of (-)-3 perchlorate revealed that it possesses the 5S,6S absolute configuration.It was found that

Full text of DOI:10.1021/jm00348a015

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