Synthesis, X-Ray Crystallographic Determination, and Opioid Activity of erythro-5-Methylmethadone Enantiomers. Evidence Which Suggests That μ and δ Opioid Receptors Possess Different Stereochemical Requirements

DOI: 10.1021/jm00348a015

Source and publish data:

Journal of Medicinal Chemistry p. 684 - 688 (1982)

Update date:2022-08-03

Topics:

Authors:

Portoghese, P. S.

Poupaert, J. H.

Larson, D. L.

Groutas, W. C.

Meitzner, G. D.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00348a015

Enantiomers of erythro-5-methylmethadone (3) were synthesized from optical antipodes of erythro-3-(dimethylamino)-2-butanol.X-ray crystallographic analysis of (-)-3 perchlorate revealed that it possesses the 5S,6S absolute configuration.It was found that

Full text of DOI:10.1021/jm00348a015

Products guided by the article

Product name:methyl (-)-erythro-2,2-diphenyl-3-methyl-4-(dimethylamino)valerate

Cas No:81441-25-0

R&D Labs maybe for 81441-25-0

Hubei Danao Pharmaceutical Co.,Ltd.

website:http://www.danaopharm.com

Contact:+86-719-5251167

Address:Fandan Road,Danjiangkou,Hubei
Taizhou Sunny Chemical Co.,Ltd

Contact:+86-523-86920899 +86-13951172783

Address:No.11 Xingyuang road, Gaoyong Chemical Industry Park, Gaogang Jiangsu China
xujianqiang

Contact:86-21-57725962

Address:shanghai
Henan Yellow River New Material Technology Co.Ltd.

website:http://www.yellowriverchem.com

Contact:0086-373-7278760

Address:Chengguan Town, Yuanyang County
Chungking Joyinchem Co., Ltd.

Contact:+86-23-77778019

Address:No. 55, Longhu Road, Xiangkou Town, Wulong District, Chungking City, 408500, P.R China

Relevant to this article

Synthesis of 7-<3-amino-2,3,6,trideoxy-4-O-(2,6-dideoxy-α-L-lyxo-hexopyranosyl)-α-L-lyxo-hexopyranosyl>daunomycine

Doi:10.1016/S0008-6215(00)80810-1
(1982)
A new solid-phase reaction system utilizing a temperature-responsive catalyst: Oxidative cyclization with hydrogen peroxide

Doi:10.1002/adsc.200700114
(2007)
SYNTHESIS OF γ-KETOPIMELIC ACID DERIVATIVES BY RHODIUM CARBONYL-CATALYZED HYDROCARBONYLATION OF ACRYLIC ACID DERIVATIVES

Doi:10.1246/cl.1982.361
(1982)
Thermal studies on solid complexes of saccharin with divalent transition metal ions

Doi:10.1023/A:1010190701136
(1998)
SYNTHESIS OF NUCLEOSIDE 5'-(β-D-GLUCOPYRANOSYL MONOPHOSPHATES) BY THE SUGAR ORTHO ESTER ROUTE

Doi:10.1016/S0008-6215(00)88057-X
(1982)
Indolyl compounds as antiinflammatory agents

Doi:10.1002/ardp.19823150414
(1982)

Article Doi