Species- or Isozyme-Specific Enzyme Inhibitors. 5. Differential Effects of Thymidine Substituents on Affinity for Rat Thymidine Kinase Isozymes

DOI: 10.1021/jm00348a007

Source and publish data:

Journal of Medicinal Chemistry p. 644 - 649 (1982)

Update date:2022-08-03

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Authors:

Hampton, Alexander

Chawla, Ram R.

Kappler, Francis

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Article abstract of DOI:10.1021/jm00348a007

Derivatives obtained by single replacements or substitutions of groups at eight positions of thymidine (TdR) have been examined as inhibitors of rat mitochondrial (M-TK) and cytoplasmic (C-TK) isozymes of thymidine kinase.A C-TK (pI = 7.5) and an M-TK (pI

Full text of DOI:10.1021/jm00348a007

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