Species- or Isozyme-Specific Enzyme Inhibitors. 5. Differential Effects of Thymidine Substituents on Affinity for Rat Thymidine Kinase Isozymes

Article abstract of DOI:10.1021/jm00348a007

Derivatives obtained by single replacements or substitutions of groups at eight positions of thymidine (TdR) have been examined as inhibitors of rat mitochondrial (M-TK) and cytoplasmic (C-TK) isozymes of thymidine kinase.A C-TK (pI = 7.5) and an M-TK (pI