Species- or Isozyme-Specific Enzyme Inhibitors. 5. Differential Effects of Thymidine Substituents on Affinity for Rat Thymidine Kinase Isozymes

DOI: 10.1021/jm00348a007

Source and publish data:

Journal of Medicinal Chemistry p. 644 - 649 (1982)

Update date:2022-08-03

Topics:

Authors:

Hampton, Alexander

Chawla, Ram R.

Kappler, Francis

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00348a007

Derivatives obtained by single replacements or substitutions of groups at eight positions of thymidine (TdR) have been examined as inhibitors of rat mitochondrial (M-TK) and cytoplasmic (C-TK) isozymes of thymidine kinase.A C-TK (pI = 7.5) and an M-TK (pI

Full text of DOI:10.1021/jm00348a007

Products guided by the article

Product name:5'-O-trityl-3'-O-methyl-2'-deoxyuridine

Cas No:81542-74-7

R&D Labs maybe for 81542-74-7

Suzhou Kangrun Pharmaceutical, Inc

Contact:86-512-63912376，63913329

Address:Building 2, No. 2358 ,Chang'an Rd, Wujiang Economic Development Zone Pioneering park, china
ALPHA PHARMACEUTICAL CO，LTD JIANGSU

Contact:+86-527-84829968,+86-527-84829998

Address:suqian city
Heliosense Biotechnologies, Inc.

website:https://www.heliosense.com/

Contact:+86-592-5667290

Address:Xiamen Torch Hi-tech Zone Venture Weiye Building S506
Hawks Chemical

Contact:+44 (0)161 367 9441

Address:
Taizhou YOJOY Chemical Co., Ltd.

Contact:13857143241

Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China

Relevant to this article

Catalytic asymmetric hydrogenation of 3-ethoxycarbonyl quinolin-2-ones and coumarins

Doi:10.1021/acs.orglett.1c00993
(2021)
SYNTHESIS AND BIOLOGICAL TESTING OF 4-CARBOXYQUINOLYL-2-ALDEHYDE DERIVATIVES

Doi:10.1007/BF00762028
(1982)
ORGANOMETALLIC REACTION MECHANISMS. XVIII. CONCERNING THE NATURE OF THE TRANSITION STATE IN THE REACTION OF TRIALKYLALUMINUM COMPOUNDS WITH KETONES

Doi:10.1016/S0022-328X(00)86812-6
(1982)
New C-arylation reaction found during a study on the interaction of aldohydrazones and arenediazonium chlorides

Doi:10.1070/MC2006v016n05ABEH002397
(2006)
PREPARATION OF 3-CHLORO-2-METHYL-1-SELENOPHENYLPROPENE, A NEW EQUIVALENT OF METHACROLEIN. APPLICATION TO THE REGIOSPECIFIC SYNTHESIS OF A MODEL OF THE SELAGINE RING SYSTEM.

Doi:10.1016/S0040-4039(00)81502-6
(1983)
A Novel Synthesis of 3-Aryl-1,2,4-benzotriazines via N-Phenylsulfonyl-N''-arylbenzamidrazones

Doi:10.1246/bcsj.55.859
(1982)

Article Doi