Tryptophan Analogues. 1. Synthesis and Antihypertensive Activity of Positional Isomers

DOI: 10.1021/jm00348a022

Source and publish data:

Journal of Medicinal Chemistry p. 723 - 730 (1982)

Update date:2022-07-30

Topics:

Authors:

Safdy, Max E.

Kurchacova, Elva

Schut, Robert N.

Vidrio, Horacio

Hong, Enrique

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Article abstract of DOI:10.1021/jm00348a022

A series of tryptophan analogues having the carboxyl function at the β position was synthesized and tested for antihypertensive activity.The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue.The methyl ester was found to be a critical structural feature for activity.

Full text of DOI:10.1021/jm00348a022

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