Tryptophan Analogues. 1. Synthesis and Antihypertensive Activity of Positional Isomers

Article abstract of DOI:10.1021/jm00348a022

A series of tryptophan analogues having the carboxyl function at the β position was synthesized and tested for antihypertensive activity.The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue.The methyl ester was found to be a critical structural feature for activity.