Journal of Medicinal Chemistry p. 723 - 730 (1982)
Update date:2022-07-30
Topics:
Safdy, Max E.
Kurchacova, Elva
Schut, Robert N.
Vidrio, Horacio
Hong, Enrique
A series of tryptophan analogues having the carboxyl function at the β position was synthesized and tested for antihypertensive activity.The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue.The methyl ester was found to be a critical structural feature for activity.
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