Synthetic studies on arene-olefin cycloadditions. II. Total synthesis of (±)-isocomene

Article abstract of DOI:10.1016/0040-4020(81)80011-7

The arene-olefin meta-photocycloaddition is shown to provide the basis for an effective and general approach to polyquinane natural products as demonstrated by the synthesis of (±)-isocomene (5) in five steps based on Z-2-bromo-2-butene and 2-bromotoluene