C-C - CONNECTIVE SYNTHESIS OF α-DIALKYLAMINO - KETONES FROM ALDEHYDES AND SEC.-AMINES

DOI: 10.1016/S0040-4039(00)86910-5

Source and publish data:

Tetrahedron Letters p. 639 - 642 (1982)

Update date:2022-08-05

Topics:

Authors:

Enders, Dieter

Lotter, Hermann

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Article abstract of DOI:10.1016/S0040-4039(00)86910-5

A simple and efficient 3 - step synthesis of α-dialkylamino - ketones 3 starting from aldehydes and sec.-amines is described.The unsymmetrically aminoketones are obtained as pure regioisomers via reaction of metalated α-aminonitriles 1 with aldehydes, followed by thermal HCN-elimination/tautomerization.

Full text of DOI:10.1016/S0040-4039(00)86910-5

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