DIRECT GAS-CHROMATOGRAPHIC RESOLUTION OF DL-myo-INOSITOL 1-PHOSPHATE AND OTHER SUGAR ENANTIOMERS AS SIMPLE DERIVATIVES ON A CHIRAL CAPILLARY COLUMN

Article abstract of DOI:10.1016/S0008-6215(00)80683-7

A commercailly avialable, chiral stationary-phase was used to separate sugar enatiomers.Derivatives commonly used for the gas chromatography of carbohydrates were employed.The most generally useful was found to be the per(heptafluorobutanoyl)derivative, in wich form D- and L-arabinose, fucose, xylose, mannose, and chiro-inositol were well resolved.The D and L enantiomers of glucose were best separated as 6-O-trimethylsilyl-α-glucofuranose 1,2:3,5-bis(methaneboronate).DL-myo-Inositol 1-phosphate was well resolved as the 2,3,4,5,6-penta-O-(trimethylsilyl)-1-dimethylphosphate.Other derivatives were less well resolved, and some sugar enantiomers could not be separated by the means used.