Acylation of 2H,6H-2,6-Dimethyl-4-amino-1,3,5-dithiazine and Tautomerism of the Reaction Products

Article abstract of DOI:10.1007/BF00526078

The acylation of 2H,6H-2,6-dimethyl-4-amino-1,3,5-dithiazine with the chlorides and anhydrides of saturated carboxylic and sulfonic acids leads to N-monoacyl derivatives of dithiazine in 85-96percent yields.It was established by IR and UV spectroscopy that 2H,6H-2,6-dimethyl-4-acylamino-1,3,5-dithiazines with donor substituents exist primarily in the amino form and that the equilibrium is shifted to favor the imino form for compounds with acceptor substituents to a greater degree in solutions that in the crystalline state.