Bioorganic and Medicinal Chemistry Letters p. 115 - 119 (2005)
Update date:2022-09-26
Topics:
Shipps Jr., Gerald W.
Deng, Yongqi
Wang, Tong
Popovici-Muller, Janeta
Curran, Patrick J.
Rosner, Kristin E.
Cooper, Alan B.
Girijavallabhan, Viyyoor
Butkiewicz, Nancy
Cable, Michael
Aminothiazole-based inhibitors designed for HCV polymerase display low micromolar potencies in biochemical assays. These compounds show a stringent preference for a cyclohexyl hydrophobe at the 2-amino position. The composition of these compounds suggests that they may be interacting at a recently discovered allosteric site on the polymerase.
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Doi:10.1021/ja00388a114
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