Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-N-oxide as selective glycine antagonists

DOI: 10.1016/S0960-894X(96)00492-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2749 - 2754 (1996)

Update date:2022-08-04

Topics:

Authors:

Cugola, Alfredo

Donati, Daniele

Guarneri

Micheli, Fabrizio

Missio, Andrea

Pecunioso, Angelo

Reggiani, Angelo

Tarzia Tarzia

Zanirato

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Article abstract of DOI:10.1016/S0960-894X(96)00492-1

Pyrido[2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor.

Full text of DOI:10.1016/S0960-894X(96)00492-1

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Product name:5-Chloro-4,6-diMethylpyridine-2,3-diaMine

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