Journal of Organic Chemistry p. 289 - 294 (1983)
Update date:2022-09-26
Topics:
Hart, David J.
Kanai, Ken-ichi
Thomas, Dudley G.
Yang, Teng-Kuei
Nonenolizable aldehydes react with lithium bis(trimethylsilyl)amide at ambient temperatures to afford solutions of N-trimethylsilyl aldimines.Treatment of these solutions with Grignard reagents or alkyllithiums followed by an aqueous workup gives primary amines in moderate to excellent yields.Treatment of N-trimethylsilyl aldimines with ester enolates provides an expedient route to 1-unsubstituted 2-azetidinones.
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Doi:10.1002/mrc.1270200206
(1982)Doi:10.1021/ja01145a010
(1951)Doi:10.1021/jm00385a023
(1987)Doi:10.1039/b909803h
(2009)Doi:10.1002/jlcr.843
(2004)Doi:10.1021/jo00154a010
(1983)
