SYNTHESIS OF 3-AMINO-2,3,6-TRIDEOXY-L-lyxo-HEXOSE (DAUNOSAMINE) HYDROCHLORIDE FROM D-GLUCOSE

Article abstract of DOI:10.1016/S0008-6215(00)80395-X

Three different approaches starting from 1,2-O-isopropylidene-α-D-glucofuranose were tested for the synthesis of daunosamine hydrochloride (24), the sugar constituent of the antitumor antibiotics daunomycin and adriamycin.The third route, affording 24 in