Enantioselective telomerization 1. Telomerization of butadiene with formaldehyde, β-dicarbonyl compounds, nitroalkanes, and enamines

Article abstract of DOI:10.1016/0022-328X(90)85233-O

Enantioselective telomerization reactions catalyzed by homogeneous palladium catalysts are described.Applying the concept of chiral bidentate phosphorus ligands and low temperatures proved useful in telomerizing butadiene with formaldehyde, with a β-dicarbonyl compound and with a nitroalkane.Excess of enantiomers up to 41percent could be obtained.With a chiral enamine as nucleophile ee values of 72percent have been observed.