Chemistry of Four-Membered Cyclic Nitrones. 4. Reaction with Electrophilic Reagents and Conversion into β-Lactam Derivatives

Article abstract of DOI:10.1021/jo00152a015

The conversion of the four-membered cyclic nitrone 1a into a β-lactam has been investigated by using several electrophilic reagents.With methanesulfonyl chloride or with acetic acid, 1a reacts to give the oxime 2.In acetic acid this oxime undergoes cycliz