Stereoselective Construction of γ-Lactams via Copper-Catalyzed Borylacylation

DOI: 10.1021/acs.orglett.0c02837

Source and publish data:

Organic Letters p. 7915 - 7919 (2020)

Update date:2022-08-03

Topics:

Authors:

Bajohr, Jonathan

Lautens, Mark

Polishchuk, Iuliia

Torelli, Alexa

Whyte, Andrew

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Article abstract of DOI:10.1021/acs.orglett.0c02837

A versatile and highly stereoselective borylative cyclization to generate polyfunctionalized γ-lactams has been developed. The stereoselective synthesis of these key ring systems is crucial due to their ubiquity in natural products. We report the diastero- and enantioselective construction of di- and trisubstituted γ-lactam cores, with examples containing an enantioenriched quaternary carbon.

Full text of DOI:10.1021/acs.orglett.0c02837

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