STEREOSELECTIVE ALKYLATION OF THE LITHIUM DI-ENOLATE OF BIS-2,3-CARBOMETHOXY BICYCLOHEPT-5-ENE. A CONVENIENT SYNTHESIS OF MONO- AND DISUBSTITUTED FUMARATE ESTERS.

DOI: 10.1016/S0040-4039(00)88657-8

Source and publish data:

Tetrahedron Letters p. 3683 - 3686 (1982)

Update date:2022-09-26

Topics:

Authors:

Girard, C.

Bloch, R.

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Article abstract of DOI:10.1016/S0040-4039(00)88657-8

The diesters formed by a Diels-Alder reaction between cyclopentadiene and methyle maleate or fumarate give the same lithium dienolate which is stereoselectively mono- or dialkylated.The products obtained are good precursors for substituted fumarate esters.

Full text of DOI:10.1016/S0040-4039(00)88657-8

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