Bioorganic and Medicinal Chemistry Letters p. 1075 - 1078 (2005)
Update date:2022-09-26
Topics:
Razavi, Hossein
Powers, Evan T.
Purkey, Hans E.
Adamski-Werner, Sara L.
Chiang, Kyle P.
Dendle, Maria T. A.
Kelly, Jeffery W.
Ten oxazoles bearing a C(4) carboxyl group were synthesized and evaluated as transthyretin (TTR) amyloid fibril inhibitors. Substituting aryls at the C(2) position of the oxazole ring reveals that a 3,5-dichlorophenyl substituent significantly reduced amy
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