THE CHEMICAL SYNTHESIS OF THE Rp AND Sp DIASTEREOMERS OF THYMIDYL-(3'-5')THYMIDYL O,O-PHOSPHOROTHIOATE

DOI: 10.1016/S0040-4039(00)88727-4

Source and publish data:

Tetrahedron Letters p. 4289 - 4292 (1982)

Update date:2022-08-03

Topics:

Authors:

Uznanski, Bogdan

Niewiarowski, Wojciech

Stec, Wojciech J.

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Article abstract of DOI:10.1016/S0040-4039(00)88727-4

The synthesis and separation of diastereomers of protected thymidyl-(3'-5')thymidyl O,O-phosphoranilidate (4) allowed to obtain in the stereospecific manner title compounds 5, whose absulute configuration at P atom was assigned enzymatically.T_P(S)T diastereomers (5) were obtained independently via "phosphite" procedure.

Full text of DOI:10.1016/S0040-4039(00)88727-4

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