Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing α-methylphenylalanyl based phosphotyrosyl mimetics

DOI: 10.1021/jm0492709

Source and publish data:

Journal of Medicinal Chemistry p. 764 - 772 (2005)

Update date:2022-07-29

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Authors:

Oishi, Shinya

Karki, Rajeshri G.

Kang, Sang-Uk

Wang, Xiangzhu

Worthy, Karen M.

Bindu, Lakshman K.

Nicklaus, Marc C.

Fisher, Robert J.

Burke Jr., Terrence R.

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Article abstract of DOI:10.1021/jm0492709

Previous work has shown that incorporation of either 1- aminocyclohexanecarboxylic acid (Ac₆c) or α-methyl-p- phosphonophenylalanine ((α-Me)Ppp) in the phosphotyrosyl (pTyr) C-proximal position (pY + 1 residue) of Grb2 SH2 domain binding peptid

Full text of DOI:10.1021/jm0492709

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