DIMETALATED TERTIARY SUCCINAMIDES. SYNTHESIS OF SEVERAL CLASSES OF LIGNANS INCLUDING THE MAMMALIAN URINARY LIGNANS ENTEROLACTONE AND ENTERODIOL

Article abstract of DOI:10.1016/S0040-4039(00)88673-6

Reaction of dimetalated succinamides with benzyl halides and aromatic aldehydes provides short routes to diverse lignan natural products 2, 3, and 4a, including the human urinary metabolites (3d) and (2e).