Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives

DOI: 10.1016/j.bmcl.2021.128083

Source and publish data:

Bioorganic and Medicinal Chemistry Letters (2021)

Update date:2022-07-30

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Authors:

Cui, Yong-Mei

Ji, Tong-Tong

Jo, Heeji

Lin, Hai-Xia

Park, Chul-Seung

Qi, Xiao-Lei

Wang, Xue-Ying

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Article abstract of DOI:10.1016/j.bmcl.2021.128083

A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.

Full text of DOI:10.1016/j.bmcl.2021.128083

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