Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases

Article abstract of DOI:10.1021/jm00398a022

Two new inhibitors, 4 and 5, of the aspartic proteinase porcine pepsin were synthesized. These compounds, which span the P₄-P'₃ binding subsites of the enzyme, were derived by replacing the Nph-Phe dipeptidyl unit of a good pepsin su