Helvetica Chimica Acta p. 2512 - 2518 (1983)
Update date:2022-08-04
Topics:
Fehr, Charles
Intramolecular Grignard-type reaction of the bromolactones 3 and 8 affords the macrocycles 10, 11, 12 and 13, 14, 15, respectively.More efficiently, 10 and 13 are obtaine by intramolecular nucleophilic attack of the carbanions derived from the sulfonyl lactones 20 and 22 and in situ reduction of the intermediate sulfones 21 and 23.The macrocyclic hydroxy ketones 10 and 13 are converted into ExaltoneR (2) muscone(1), respectively.
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