A STEREOCONTROLLED SYNTHESIS OF 2-METHYL-ALKENENITRILES FROM C-METHYL-C, N-BIS(TRIMETHYLSILYL)KETENIMINE AND ALDEHYDES

DOI: 10.1246/cl.1983.97

Source and publish data:

Chemistry Letters p. 97 - 100 (1983)

Update date:2022-08-05

Topics:

Authors:

Okada, Hisashi

Matsuda, Isamu

Izumi, Yusuke

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/cl.1983.97

A stereocontrolled synthesis of 2-methyl-2-alkenenitriles is achieved via the diastereoselective aldol type reaction of C-methyl-C,N-bis(trimethylsilyl)ketenimine with aldehydes in the presence of a mixture of TiCl4 and Ti(O-iPr)4.

Full text of DOI:10.1246/cl.1983.97

Products guided by the article

Product name:(Z)-2-methyl-5-phenylpent-2-enenitrile

Cas No:85054-79-1

R&D Labs maybe for 85054-79-1

Shanxi Tongji Pharmaceuticals Co., Ltd.

Contact:+86-359-3024784

Address:Xikuang South Road, Ruicheng County , Shanxi
Jinan Yijialian Economic and Trade Development Co., Ltd.

Contact:+86 0531-66729596

Address:jinan
Zibo Linzi Darong Fine Chemical Co., Ltd(expird)

Contact:86-532-67773200; 15689126900

Address:Qidu town,Linzi district,Zibo city,Shandong province,China
Guangzhou Reachin Chemical Co., Ltd

Contact:+86-20-37087379 ext.604

Address:A122C-1, Tianyuan Plaza, 401 Tianyuan Rd., Tianhe, Guangzhou, China
Josun International Limited

website:http://www.josunpharma.com

Contact:+86-311-80715268 80766839

Address:No.39, Zhaiying Street, Shijaizhuang,Hebei,China

Relevant to this article

Side-chain conformational restriction in template-competitive inhibitors of E. coli DNA polymerase I Klenow fragment: Synthesis, structural characterization and inhibition activity

Doi:10.1081/NCN-200034042
(2004)
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease

Doi:10.1016/j.bmcl.2004.09.006
(2004)
Zirconocene-mediated intermolecular coupling of Si-tethered diynes with alkynes, ketones, aldehydes, and isocyanates by means of novel skeletal rearrangement of zirconacyclobutene-silacyclobutene and zirconacyclohexadiene- silacyclobutene fused-ring intermediates

Doi:10.1002/chem.200400697
(2005)
Efficient methods for the synthesis of 2-hydroxyphenazine based on the Pd-catalyzed N-arylation of aryl bromides

Doi:10.1021/ol050198y
(2005)
A homo-proline tetrazole as an improved organocatalyst for the asymmetric Michael addition of carbonyl compounds to nitro-olefins

Doi:10.1055/s-2005-862392
(2005)
Discovery of novel picolinamide-based derivatives as novel VEGFR-2 kinase inhibitors: Synthesis,: in vitro biological evaluation and molecular docking

Doi:10.1039/c8md00057c
(2018)

Article Doi