A STEREOCONTROLLED SYNTHESIS OF 2-METHYL-ALKENENITRILES FROM C-METHYL-C, N-BIS(TRIMETHYLSILYL)KETENIMINE AND ALDEHYDES

DOI: 10.1246/cl.1983.97

Source and publish data:

Chemistry Letters p. 97 - 100 (1983)

Update date:2022-08-05

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Authors:

Okada, Hisashi

Matsuda, Isamu

Izumi, Yusuke

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Article abstract of DOI:10.1246/cl.1983.97

A stereocontrolled synthesis of 2-methyl-2-alkenenitriles is achieved via the diastereoselective aldol type reaction of C-methyl-C,N-bis(trimethylsilyl)ketenimine with aldehydes in the presence of a mixture of TiCl4 and Ti(O-iPr)4.

Full text of DOI:10.1246/cl.1983.97

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