STRUCTURE AND SYNTHESIS OF REDUCTILINE, A NOVEL METABOLITE FROM A VARIANT OF STREPTOMYCES ORIENTALIS

DOI: 10.1016/S0040-4039(00)85765-2

Source and publish data:

Tetrahedron Letters p. 4977 - 4980 (1982)

Update date:2022-08-04

Topics:

Authors:

Ojika, Makoto

Shizuri, Yoshikazu

Niwa, Haruki

Yamada, Kiyoyuki

Iwadare, Shuichi

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Article abstract of DOI:10.1016/S0040-4039(00)85765-2

The structure of reductiline, a metabolite of a variant of Streptomyces orientalis was elucidated as (1) based on chemical and spectroscopic evidence.Transformation of an antitumor antibiotic reductiomycin (2) into reductiline (1) was carried out.Synthesis of reductiline (1) was achieved starting from β-cyanopropionaldehyde dimethylacetal.

Full text of DOI:10.1016/S0040-4039(00)85765-2

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