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160.6 (C-7), 152.3 (C-8a), 151.5 (C-5), 133.8 (C-400), 131.9
(C-40), 130.8 (C-10), 129.7 (C-200,600), 129.1 (C-30,50), 128.8
(C-300,500), 128.6 (C-100), 126.4 (C-20,60), 122.5 (C-6), 104.7
(C-4a), 102.0 (C-3), 98.8 (C-8), 54.8 (C-11,14), 53.3 (C-9),
26.2 (C-12,13). HRMS (ESI) m/z [M + H]+ Calcd for
C27H24NO6S : 490.1324, found : 490.1346.
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In summary, 7-ester-8-aminomethylene-substituted baicalein
derivatives (1) were successfully synthesized by a Mannich
1
reaction, followed by esterification. Comparison of the H,
13C-NMR, HMBC data, and strontium chloride reactivity of
1 with those of the 7-ester derivatives 3 confirmed the
proposed structure of 1.
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ACKNOWLEDGEMENTS
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ucts, Vol. 6, Peoples Medical Publishing House Co., LTD,
Beijing 2012, p. 197.
The authors acknowledge the financial support from the
National Natural Science Foundation of China (Grant
No. 21502142). Prof. Yi Zhang is acknowledged for the
structural analysis of compound 1.
SUPPORTING INFORMATION
Additional supporting information may be found in the
online version of the article at the publisher's website.
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