Journal of the Chemical Society. Chemical communications p. 1657 - 1658 (1990)
Update date:2022-08-05
Topics: Alkylation Chiral Enantioselective Base Cyclic Ketones Lithium Bromide Lithium amide
Murakata, Masatoshi
Nakajima, Makoto
Koga, Kenji
An efficient enantioselective alkylation reaction at the α-position of cyclic ketones (1, 2) can be realized in up to 92percent enantiomeric excess (e.e) by first forming their lithium enolates using a chiral lithium amide 4 in the presence of lithium bromide, followed by treatment with alkyl halides.
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