Synthesis of lipid a analogues containing glucose instead of glucosamine and their LPS-antagonistic activities

DOI: 10.1016/j.tet.2005.03.034

Source and publish data:

Tetrahedron p. 5101 - 5122 (2005)

Update date:2022-09-26

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Authors:

Shiozaki, Masao

Watanabe, Yukiko

Iwano, Yuji

Kaneko, Toshio

Doi, Hiromi

Tanaka, Daisuke

Shimozato, Takaichi

Kurakata, Shin-Ichi

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Article abstract of DOI:10.1016/j.tet.2005.03.034

Lipid A analogues containing glucose in substitution for glucosamine on the reducing end were synthesized, and the inhibitory activities on LPS-induced TNFα production (LPS-antagonistic activity) in vitro using human whole blood cells were measured. The I

Full text of DOI:10.1016/j.tet.2005.03.034

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