Identification of active-site inhibitors of MurG using a generalizable, high-throughput glycosyltransferase screen

Article abstract of DOI:10.1021/ja036494s

MurG is a glycosyltransferase involved in the biosynthesis of bacterial peptidoglycan. It is a potentially important antibiotic target, but no inhibitors of the enzyme have been reported. In general, inhibitors of glycosyltransferases have been difficult