
Journal of Organic Chemistry p. 2138 - 2140 (1983)
Update date:2022-08-03
Topics:
Essawi, M. Y. H.
Portoghese, P. S.
The stereochemistry of cyanide ion addition to 1-alkyl-4-(N-phenylpropanamido)-3,4,5,6-tetrahydropyridinium salts 2 was investigated by analysis of the 1H NMR spectra of the isolated α-amino nitriles.The data obtained, together with epimerization studies, indicated that the addition occurred in a stereospecific manner to afford the trans diastereoisomeres.
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