Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of the Unprotected Cyclopropapyrroloindole A Portion Using the 3,3'-Bipyrrole Strategy

DOI: 10.1021/ja00243a025

Source and publish data:

Journal of the American Chemical Society p. 2706 - 2711 (1987)

Update date:2022-08-03

Topics:

Authors:

Magnus, Philip

Gallagher, Timothy

Schultz, James

Or, Yat-Sun

Ananthanarayan, T.P.

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Article abstract of DOI:10.1021/ja00243a025

The total synthesis of the unprotected A portion of the potent cytotoxic agent CC-1065 1 using the 3,3'-bipyrrole strategy is described.Treatment of ethyl sorbate with (p-tolylsulfonyl)methyl isocyanide (TosMIC)/NaH gave the pyrrole 7, which was N'-phenyl

Full text of DOI:10.1021/ja00243a025

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