Bioorganic and Medicinal Chemistry Letters p. 2925 - 2930 (1996)
Update date:2022-09-26
Topics:
Suto, Mark J.
Sullivan, Robert W.
Ransone, Lynn J.
A series of tripeptides (Z-LLF-R) with various modifications at their C-terminus were synthesized and evaluated for their ability to prevent the activation of NF-κB through inhibition of IκB protease. Of the compounds evaluated only the C-terminal aldehydes 5a,b were active in our Jurkat T-cell based assay. Compounds 5a also decreased IL-2 and IL-8 levels in these cells indicating that inhibitors of IκB protease can have an effect on various signalling pathways.
View MoreContact:+86-531-58668191 58668193 58668196 58661173
Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province
shandong lukang animal & plant drug trading co.,ltd.
Contact:15853765968
Address:floor 9, lukang ,jingying building,#173,taibai building west road,jining city,shandong,china
Contact:+49-9398-993127
Address:Untertorstr. 27
HENAN NEW BLUE CHEMICAL CO.,LTD
website:http://www.newbluechem.com
Contact:86-371-55170693/55170694
Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.
Contact:+86-21-51320130-801, 816
Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Doi:10.1021/ja01174a003
(1949)Doi:10.1021/acs.orglett.9b03102
(2019)Doi:10.1021/ic050037q
(2005)Doi:10.1002/jhet.1893
(2014)Doi:10.1016/j.jorganchem.2005.03.056
(2005)Doi:10.1016/j.ejps.2004.11.006
(2005)
