Bioorganic and Medicinal Chemistry Letters p. 2925 - 2930 (1996)
Update date:2022-09-26
Topics:
Suto, Mark J.
Sullivan, Robert W.
Ransone, Lynn J.
A series of tripeptides (Z-LLF-R) with various modifications at their C-terminus were synthesized and evaluated for their ability to prevent the activation of NF-κB through inhibition of IκB protease. Of the compounds evaluated only the C-terminal aldehydes 5a,b were active in our Jurkat T-cell based assay. Compounds 5a also decreased IL-2 and IL-8 levels in these cells indicating that inhibitors of IκB protease can have an effect on various signalling pathways.
View MoreShanghai PotentPharm Science and Technology Co.,Ltd
Contact:86-021-51969655
Address:Unit B, Building 18, No.300, Chuantu Rd,Pudong District, Shanghai 201202, China
Qingdao XinYongAn Chemicals Co., Ltd
Contact:+86-532-81107967
Address:Chengyang dual-port industrial park by the sea，Qingdao
Dezhou Longteng Chemical Co., Ltd.
website:http://www.sodium-methoxide.cn/
Contact:0086-18866052283
Address:Xinhua Industrial Zone, Dezhou City, Shandong Province, China
Shanghai Pengkai Chemical Co.,Ltd
Contact:+86-21-60526671
Address:No.4226 Duzhuang Rd Minhang District Shanghai China
Guangxi Shanyun Biochemical Science and Technology Co., Ltd
Contact:+86-0772--6828887
Address:#2 Industrial Park of Luzhai County, Liuzhou, Guangxi, China
Doi:10.1021/ja01174a003
(1949)Doi:10.1021/acs.orglett.9b03102
(2019)Doi:10.1021/ic050037q
(2005)Doi:10.1002/jhet.1893
(2014)Doi:10.1016/j.jorganchem.2005.03.056
(2005)Doi:10.1016/j.ejps.2004.11.006
(2005)
