Synthesis of some new 2-(phenoxyacetylthio)-3-aryl-6-bromo- or 6,8-dibromoquinazoline-4(3H)-ones as possible AChE inhibitors

Article abstract of DOI:10.1002/ardp.19833160509

Sixteen new 2-(phenoxyacetylthio)-3-aryl-6-bromo- or -6,8-dibromoquinazolines were synthesized by condensation of various phenoxyacetyl chlorides with mercaptoquinazolines. Their inhibitory properties towards choline esterase and their bactericidal activities were studied in vitro. Nine of the compounds exhibited (>50%) choline esterase inhibition, whereas the antibacterial screening showed moderate results.