Tetrahedron p. 743 - 748 (1983)
Update date:2022-08-03
Topics: Synthesis Antitumor Analogues Experimental Antibiotic Chemical
Stevens, Robert V.
Polniaszek, Richard P.
Several haloisoxazoline analogues of α-amino-3-chloro-4,5-dihydro-5-isoxazole acetic acid (1, AT-125) were prepared by means of 1,3-dipolar cycloaddition methodology.The chemistry of these compounds is discussed, and a possible biological mode of action of AT-125 presented.
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