Organic Process Research and Development p. 641 - 644 (2009)
Update date:2022-07-29
Topics:
Oumata, Nassima
Ferandin, Yoan
Meijer, Laurent
Galons, Herve
Roscovitine and CR8 are potent inhibitors of cyclin-dependent kinases. A scalable synthesis of both inhibitors is described. In the case of CR8, the biarylmethylamine moiety was obtained as a stable and high-purity salt.
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