Direct synthesis of α-amino amides from N-alkyl amines by the copper-catalyzed oxidative Ugi-type reaction

Article abstract of DOI:10.1055/s-0031-1290319

α-Amino amides can be accessed directly form N-alkyl amines by the isocyanide-compatible oxidative copper-peroxide conditions even in the presence of water. Various functional groups are tolerated in the reaction, leading to the synthesis of various -amin