Synthesis of mono- and di-substituted 2,4,5-trifluorobenzoic acid synthons, key precursors for biologically active 6-fluoroquinolones

Article abstract of DOI:10.1016/j.tet.2005.06.078

In the search for new potent antiparasitical fluoroquinolones, a QSAR analysis by molecular connectivity led to the design of R⁵ (Me or Et)/R⁸ (MeO, Me or Et)-substituted analogs of the most powerful antibacterial or antiparasitical