Medicinal Chemistry Research p. 1290 - 1299 (2014)
Update date:2022-08-03
Topics: Characterization Structure-Activity Relationship (SAR) Analysis In vitro Testing Animal Studies Formulation and Delivery Literature Review Mechanism of Action Design and Synthesis Further Optimization Data Analysis and Publication Cytotoxicity Screening Regulatory Compliance
Joshi, Deepkumar
Parikh, Kalpesh
Benzimidazole analogs bearing electron-withdrawing as well as electron-donating substituent were synthesized to achieve bioactive molecules with significant antimicrobial property. The desired compounds were prepared by multi-step synthesis process. The formation of intermediates and their corresponding derivatives (III 1-13 ) was confirmed by spectral characterization such as 1H NMR, 13C NMR, mass spectra, IR, and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel of Gram-positive and Gram-negative bacteria as well as fungi. From the SAR study data, it was observed that the derivatives with electron-withdrawing functional groups were more bioactive than that with electron-donating functional groups.
View MoreHangzhou GreenCo Science & Technology Co., Ltd.
Contact:86-571-88257303
Address:1713 Room,Jingui Building,Gudun Road,Xihu District,Hangzhou,China
Contact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
Disynthesis Chemical Technology Co. Ltd.
Contact:+86-571-88194596
Address:Dengyun road 380, Gongshu district, Hangzhou city, China
Shanghai Hohance Chemical Co., ltd
Contact:13914753421
Address:Fl.5;Bld. 70, Lane 1500; Xinfei Road
Contact:86-21-50966856
Address:Building 5,300 Chuanzhan Road,Pudong New District,Shanghai
Doi:10.1016/S0960-894X(02)00646-7
(2002)Doi:10.1246/cl.1983.519
(1983)Doi:10.1016/S0022-328X(00)98727-8
(1983)Doi:10.1016/S0040-4039(00)81652-4
(1983)Doi:10.1016/j.bmc.2019.07.035
(2019)Doi:10.1021/op700091d
(2007)