ASYMMETRIC SYNTHESIS OF PROTECTED α-HYDROXYALDEHYDES FROM ACYL CHLORIDES USING p-TOLYL p-TOLYLTHIOMETHYL SULFOXIDE AS CHIRAL CARBONYL SYNTHON

Article abstract of DOI:10.1016/S0040-4039(00)81536-1

Carbonyl protected α-hydroxyaldehydes 3 were obtained in high diastereomeric purity through LiAlH₄ reduction of corresponding β-sulfoxides 2 prepared via acylation of p-tolyl p-tolylthiomethyl sulfoxide 1.