A STEREOCONTROLLED FORMAL TOTAL SYNTHESIS OF (+/-)-THIENAMYCIN

DOI: 10.1016/0040-4020(82)85029-1

Source and publish data:

Tetrahedron p. 3457 - 3463 (1982)

Update date:2022-09-26

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Authors:

Shiozaki, Masao

Hiraoka, Tetsuo

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Article abstract of DOI:10.1016/0040-4020(82)85029-1

The stereocontrolled synthesis of a key intermediate 20 for the preparation of (+/-)-thienamycin 1 is described.The key steps in the synthesis are the formation of the β-lactam ring by cyclization of the amide 5 via a complete S_N2 mechanism, an

Full text of DOI:10.1016/0040-4020(82)85029-1

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